Pain Ease is a topical aerosol anesthetic skin refrigerant. When topically applied to the skin or intact oral mucous membranes, Pain Ease creates an instantaneous cooling effect on the surface of the site by immediate evaporation of the product. The coldness decreases the nerve conduction velocity of the C fibers and A-delta fibers that make up the peripheral nervous system. This interrupts the nociceptive (stimuli to the brain giving rise to sensations of pain) inputs to the spinal cord. This process temporarily numbs that area. The fast evaporation rate is created by Pain Ease’s chemical blend and its unique delivery system*.

Spray Pain Ease to the site for 4 to 10 seconds from a distance of 3 to 7 inches until the skin begins to blanch. The length of time will depend on the skin’s sensitivity to cold plus a number of variables such as differences in blood flow, sensory perception, weight, fat content, metabolism etc. The practitioner needs to be observant while spraying. When the skin begins to turn white, the numbing has taken effect and it is time to stop spraying. Do not frost the skin.

When the skin blanches or begins to turn white in the center of the spraying area, the skin is sufficiently cold to numb the area.

The anesthetic property of Pain Ease lasts for up to 60 seconds.

Applying Pain Ease should be the last thing done before doing the procedure. Follow protocol when cleaning the area with an antiseptic, have all equipment ready for the procedure and then apply the Pain Ease immediately before doing the procedure.

Follow your individual protocol as to application of an antiseptic, however, it is not necessary to reclean the site after applying Pain Ease. (Refer to Next Question)

Pain Ease does not claim to be sterile but the product has passed the Microbial Limit Test in accordance with the USP. These tests are designed to demonstrate that a substance is free from Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella species*.

Yes, because the can does not come in direct contact with the site (it is held between 3 to 7 inches from the site) it can be used between individual patients. Also, the design of the aerosol can and valve does not allow the ingress of substances into the can.

No, because the can does not come in direct contact with the site (it is held between 3 to 7 inches from site) it can be used between individual patients without cross contamination. The design of the Pain Ease valve is such that it does not allow any type of substance to enter its opening.

Yes, Pain Ease can be reapplied per directions, as needed, if a procedure takes longer than anticipated.

Pain Ease is contraindicated for patients who have a history of hypersensitivity to 1,1,1,3,3- Pentafluoropropane and 1,1,1,2-Tetrafluoroethane. If skin irritation develops, discontinue use. Consult the product insert, found in the cap, for a full listing/identification of all contraindications, warnings, precautions and adverse reactions.

Yes, Pain Ease is indicated for minor open wounds, intact mucous membranes (nasal passages, lips and oral cavity) and skin. There is no systemic toxicity.

No, Pain Ease is a topical spray and affects only the surface of the skin.

There is no systemic toxicity associated with Pain Ease. It is also non-ozone depleting and non-flammable. Refer to the Technical Data report for results of the toxicity studies.

No. Pain Ease is not flammable. Pain Ease is non-ozone depleting and has no systemic toxicity. It can be used in conjunction with ultrasound, x-ray, laser equipment and cautery (See Question 18).

Using the mist or stream is a personal choice of the practitioner. They both are topical anesthetic sprays. However, Pain Ease mist is most effective for cooling the site where precise contact is not needed. The area covered is larger than the stream, approximately the size of a quarter. Because it is a mist, the evaporation rate is increased and there is more intense cooling in that area.

The Pain Ease stream is most effective for cooling a pinpoint area. Gebauer Company recommends the mist to be used for a pre-injection anesthetic or for minor surgery procedures, but it is the choice of the practitioner.

Yes, since it is non-flammable, Pain Ease can be used with cautery equipment. When using cautery equipment, special care should be taken to determine that the product has completely evaporated from the surface of the site to prevent possible decomposition due to extreme heat*.

Yes, Pain Ease is non-flammable and can be used as a topical anesthetic prior to minor surgical procedures using laser equipment.

Yes, Pain Ease may be used for pre-injection anesthesia before accessing a port. (Follow your facility’s particular protocol.) Follow the application directions for pre-injection anesthesia (See Questions 3, 4, 5 and 6). Be aware that skin covering a port may be more sensitive and may respond more rapidly to the cold temperature of Pain Ease. Be observant when applying Pain Ease. Gebauer’s Pain Ease should only be sprayed on the skin covering the port, not directly on the port itself (See Question 21).

Gebauer’s Pain Ease is not indicated for spraying directly on any medical device, such as PICC lines, IV tubing or ports. Pain Ease is compatible with a variety of materials that are used to manufacture some medical devices. However, the large number of medical devices available today use a wide array of materials. Gebauer Company lacks compatibility information that would be all inclusive of every medical device material, so spraying on any medical device is not recommended.

No, Pain Ease should not be used prior to liquid nitrogen for the removal of warts in any patient population. There is no clinical data to support this indication, therefore it is unknown if there would be any adverse effects from using liquid nitrogen (cryotherapy) on skin already exposed to a skin refrigerant like Pain Ease.

Yes, Pain Ease can be used for pre-injection anesthesia prior to sclerotherapy injections and is covered under approved indications for Pain Ease use (Refer to Questions 3, 4, 5, and 6).

Approximately 50 applications are produced when spraying for an average of 5 seconds per application.

How much does Pain Ease Cost? The cost of Pain Ease will vary depending on the distributor you purchase it from and the amount used on each patient. Typically, the cost per application is as low as approximately 75 cents (Cdn) per 5-second application. This is a fraction of the cost of most if not all topical anaesthetic creams that take much longer to work.

The active ingredients of Pain Ease are 1, 1, 1, 3, 3-Pentafluoropropane and 1, 1, 1, 2-Tetrafluoroethane.

Pain Ease is an aerosol, which contains no hazardous materials. Therefore, it can be disposed of via ordinary disposal methods per your facility. Empty, partially empty or full containers with functioning valve systems may be disposed of through normal collection systems such as landfills. If the product does not have a functioning valve system, contact Gebauer Company for return instructions. The EPA recommends, but does not require, that an aerosol should be empty of product before placing in a landfill. Pain Ease should not be punctured or incinerated.

We sell our products directly to hospitals, pharmacies and medical clinics/offices as well as to a number of medical device distributors.  We are only able to sell to the end using consumer or patient who is in possession of a prescription for one of our products.